Formulations — SYLVANA | Terpene Oils for Nebulizing Diffusers

SYLVANA Forest Calm pure terpene oil in an amber 10ml bottle on wet dark stone, cedar foliage and hinoki wood beside it, misty old-growth forest behind.

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Forest Calm Oil

Forest · Calm

The walk in the woods, without the woods. Forest Calm replicates the exact phytoncide profile measured in the air of Japan's ancient hinoki forests — the compounds proven to reduce cortisol, slow heart rate, and quiet the noise of modern life.

"You just stepped off a forest trail. Shoulders drop. Breathing slows. Brain goes quiet."

VOC	Plant Source	Documented Effect
Alpha-Pinene	Pine	Cortisol reduction
Beta-Pinene	Fir	Eases anxiety
Bornyl Acetate	Spruce	Characteristic conifer-forest volatile; associated with parasympathetic response
Myrcene	Bay Leaf	Muscle relaxation
Cedrol	Cedarwood	Lowers blood pressure

2 vials · $65 / month — $32.50 each10ml Pure Oil · $42 Fits every nebulizing diffuser

The Research

Forest visits raised natural killer (NK) cell activity and anti-cancer protein expression; α-pinene and β-pinene were measured in the forest air and were near-absent in city air. Human trial Li Q, et al. Int J Immunopathol Pharmacol. 2008;21(1):117–27. doi:10.1177/039463200802100113

Cortisol, pulse rate, blood pressure and sympathetic nerve activity were lower — and parasympathetic activity higher — in forest settings than city settings, across 24 forests. 280 subjects Park BJ, et al. Environ Health Prev Med. 2010;15(1):18–26. doi:10.1007/s12199-009-0086-9

Meta-analysis of 20 trials: systolic blood pressure fell 3.15 mmHg and heart rate 3.84 bpm in forest environments versus non-forest controls. Among people with already-elevated blood pressure the drop was 6.33 mmHg. Meta-analysis · n=732 Ideno Y, et al. BMC Complement Altern Med. 2017;17(1):409. doi:10.1186/s12906-017-1912-z

Forest therapy lowered systolic/diastolic blood pressure, urinary adrenaline and serum cortisol in middle-aged males with high-normal blood pressure. Conducted in Agematsu, Kiso, Nagano — the Akasawa region. Akasawa region Ochiai H, et al. Int J Environ Res Public Health. 2015;12(3):2532–42. doi:10.3390/ijerph120302532

Cedrol inhalation decreased heart rate and blood pressure and shifted autonomic balance toward parasympathetic dominance. Human trial Dayawansa S, et al. Auton Neurosci. 2003;108(1-2):79–86. doi:10.1016/j.autneu.2003.08.002

SYLVANA Clarity pure terpene oil in an amber 10ml bottle on wet dark stone, rosemary and eucalyptus leaves beside it, misty forest behind.

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Clarity Oil

Clarity · Focus

Rosemary for remembrance. Clarity is formulated around alpha-pinene and eucalyptol — two of the most researched cognitive terpenes — to sharpen memory, cut brain fog, and sustain mental clarity without caffeine or stimulants.

"The mental version of a cold splash of water. Alert, sharp, present. Zero jitteriness — not caffeine, just clarity."

VOC	Plant Source	Documented Effect
Alpha-Pinene	Rosemary	Inhibits acetylcholinesterase in vitro — the enzyme that degrades acetylcholine
Eucalyptol	Eucalyptus	Improved behavioral scores in a nursing-home pilot study
Terpinolene	Pine	Traditional use for clarity — limited human data to date

2 vials · $65 / month — $32.50 each10ml Pure Oil · $42 Fits every nebulizing diffuser

The Research

α-Pinene and 1,8-cineole (eucalyptol) inhibited human acetylcholinesterase — the enzyme that degrades the memory neurotransmitter acetylcholine. The authors note this was measured in vitro and in-vivo relevance remains to be established. In vitro Perry NS, et al. J Pharm Pharmacol. 2000;52(7):895–902. doi:10.1211/0022357001774598

Eucalyptol diffused into nursing-home bedrooms significantly improved Dementia Behavior Disturbance scores, including among residents who never consciously perceived the scent. MMSE scores did not change. Pilot study Goto S, et al. Sci Rep. 2020;10(1):3996. doi:10.1038/s41598-020-61045-8

SYLVANA Stress Relief pure terpene oil in an amber 10ml bottle on wet dark stone, dried lavender and black peppercorns beside it, dusk-lit forest behind.

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Stress Relief Oil

Stress Relief · Unwind

Your nervous system's off switch. Stress Relief contains beta-caryophyllene — the only terpene known to directly bind CB2 receptors in your endocannabinoid system, the same pathway targeted by CBD — alongside linalool for proven cortisol reduction.

"The tension you've been carrying all day physically leaves your body. Not sleepy — just finally off."

VOC	Plant Source	Documented Effect
Linalool	Lavender	Cortisol reduction, slows heart rate
Beta-Caryophyllene	Black Pepper	CB2 endocannabinoid receptor activation
Myrcene	Hops	Quiets nervous system
Nerolidol	Jasmine	Emotional softening, anti-anxiety

2 vials · $65 / month — $32.50 each10ml Pure Oil · $42 Fits every nebulizing diffuser

The Research

Inhaled linalool measurably modulated salivary cortisol in humans under experimental stress; both enantiomers produced relaxing effects, with effects differing by chirality. Human RCT Höferl M, Krist S, Buchbauer G. Planta Med. 2006;72(13):1188–92. doi:10.1055/s-2006-947202

β-Caryophyllene binds the CB2 cannabinoid receptor selectively (Ki = 155 nM) and acts as a functional CB2 agonist — the same receptor family targeted by cannabinoids, with no psychoactive effect. Landmark paper Gertsch J, et al. Proc Natl Acad Sci USA. 2008;105(26):9099–104. doi:10.1073/pnas.0803601105

Inhaled linalool restored expression of 560 stress-induced gene probes in the hypothalamus, including anxiolytic neuropeptides oxytocin and neuropeptide Y. Animal model Yoshida K, et al. Neurosci Lett. 2017;653:314–19. doi:10.1016/j.neulet.2017.05.046

SYLVANA Mood Boost pure terpene oil in an amber 10ml bottle on wet dark stone, a curl of orange peel and glossy leaves beside it, sunlit forest behind.

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Mood Boost Oil

Mood Boost · Energy

D-limonene — the dominant terpene in citrus peel — upregulates tyrosine hydroxylase, the enzyme your brain uses to manufacture dopamine. Blood pressure begins to drop within 20 seconds of inhalation. Mood Boost is not a mood trick. It is mood chemistry.

"Like opening the blinds on a sunny morning. Warm, motivated, genuinely good — without being wired."

VOC	Plant Source	Documented Effect
D-Limonene	Orange Peel	Dominant citrus terpene; human relaxation trials in progress
Valencene	Sweet Orange	Citrus sesquiterpene — limited human data to date
Terpinolene	Pine	Limited human data to date
Beta-Pinene	Pine	Antidepressant-like effects in preclinical models

2 vials · $65 / month — $32.50 each10ml Pure Oil · $42 Fits every nebulizing diffuser

The Research

β-Caryophyllene's CB2 activity is well characterized; d-limonene's mood effects in humans remain under active investigation. A registered randomized controlled trial of limonene-dominant citrus oil inhalation is in progress. Protocol — results pending Yamaguchi F, et al. Contemp Clin Trials Commun. 2024;41:101342. doi:10.1016/j.conctc.2024.101342

Diffused tree essential oil raised NK activity and lowered urinary adrenaline and noradrenaline in a hotel room, without any forest exposure — the closest published analogue to indoor diffusion. Human trial Li Q, et al. Int J Immunopathol Pharmacol. 2009;22(4):951–9. doi:10.1177/039463200902200410

SYLVANA Euphoria pure terpene oil in an amber 10ml bottle on wet dark stone, orange peel, lavender and peppercorns beside it, golden forest light behind.

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Euphoria Oil

Euphoria · Dopamine

The full neurochemical experience. Euphoria combines d-limonene for dopamine biosynthesis with linalool for simultaneous opioid and dopamine receptor activation — your body's endorphin pathway — and beta-caryophyllene for endocannabinoid reward activation. Three pathways. One formulation.

"Not calm. Not focused. Euphoric. The feeling after a great workout, a burst of laughter, falling in love. Your brain's own reward system firing — no substances, just plants and science."

VOC	Plant Source	Documented Effect
D-Limonene	Orange Peel	Dominant citrus terpene; mechanism characterized in preclinical work
Linalool	Lavender	Alters hypothalamic oxytocin and neuropeptide Y expression (animal model)
Beta-Caryophyllene	Black Pepper	CB2 reward pathway activation
Terpinolene	Pine	Limited human data to date
Valencene	Sweet Orange	Limited human data to date

2 vials · $65 / month — $32.50 each10ml Pure Oil · $42 Fits every nebulizing diffuser

The Research

β-Caryophyllene selectively binds and activates the CB2 receptor (Ki = 155 nM), part of the endocannabinoid reward system. Landmark paper Gertsch J, et al. Proc Natl Acad Sci USA. 2008;105(26):9099–104. doi:10.1073/pnas.0803601105

CB2-selective β-caryophyllene produced measurable analgesic effects via a CB2-dependent mechanism, confirming functional receptor engagement in vivo. Animal model Klauke AL, et al. Eur Neuropsychopharmacol. 2014;24(4):608–20. doi:10.1016/j.euroneuro.2013.10.008

Inhaled linalool altered hypothalamic expression of oxytocin and neuropeptide Y under stress. Animal model Yoshida K, et al. Neurosci Lett. 2017;653:314–19. doi:10.1016/j.neulet.2017.05.046

Hardware

The SYLVANA Diffuser

Cold-Air Nebulizing

Cold-air atomization. No water, no heat, no dilution. A nebulizing diffuser uses a pressurized air stream to break pure oil into a dry micro-mist of particles small enough to stay suspended — delivering the complete terpene profile into the room without ever warming the oil.

"Scent that fills a room in seconds and reads as air, not perfume. Nothing damp. Nothing sweet. Nothing added."

Specification	Detail	Why It Matters
Atomization	Pressurized cold air	No thermal degradation of volatile terpenes
Water required	None	No dilution — full concentration delivered
Particle size	Micro-droplet mist	Stays airborne longer for sustained exposure
Oil compatibility	All SYLVANA 10ml formulations	One device, the entire collection
Operation	Intermittent cycling	Measured delivery rather than constant output

Diffuser · Coming Soon Launching with the full collection

The Research

Vaporizing hinoki cypress (Chamaecyparis obtusa) stem oil into a hotel room raised NK cell activity and lowered urinary stress hormones — demonstrating that diffused phytoncides, not the forest itself, drive the effect. α-Pinene and β-pinene were confirmed in the room air. The core proof Li Q, et al. Int J Immunopathol Pharmacol. 2009;22(4):951–9. doi:10.1177/039463200902200410

Cedrol delivered directly to the lower airway lowered blood pressure and increased baroreceptor sensitivity in laryngectomised subjects — showing terpene effects occur via the airway, not scent perception alone. Human trial Umeno K, et al. Br J Clin Pharmacol. 2008;65(2):188–96. doi:10.1111/j.1365-2125.2007.02992.x

Body Oil

Sangre

Dragon's Blood · Croton Lechleri

Every SYLVANA body oil is built around dragon's blood — Sangre de Drago, harvested from the Croton lechleri tree of the Amazon rainforest. At 2,897,110 on the ORAC scale, it is the highest antioxidant-scoring substance ever recorded in nature: 9x stronger than cloves, 550x more potent than vitamin E.

"Skin that looks calmer within minutes. A base note of resin and warmth. The forest, worn."

Body Oil · $52

The Research

Systematic review of Croton lechleri sap: in vitro, in vivo and clinical studies support wound healing, anti-inflammatory and antimicrobial uses; clinical trials reported positive results for insect-bite symptoms. Review Jones K. J Altern Complement Med. 2003;9(6):877–96. doi:10.1089/107555303771952235

Croton lechleri sap and its isolated alkaloid taspine inhibited proliferation of human melanoma and colon cancer cell lines. In vitro Montopoli M, et al. J Ethnopharmacol. 2012;144(3):747–53. doi:10.1016/j.jep.2012.10.032

Taspine averages ~9% of the latex by dry weight, but alkaloid content varies by geographic chemotype — meaning material for consistent use must be standardized. Sourcing Milanowski DJ, et al. J Nat Prod. 2002;65(6):814–19. doi:10.1021/np000270v

Compound	Source	Documented Effect
Proanthocyanidins	Croton lechleri sap	ORAC 2,897,110 — highest recorded antioxidant capacity
Taspine	Croton lechleri sap	Wound-healing, tissue repair support
Sangre de Drago lignans	Croton lechleri sap	Antimicrobial activity

Full antioxidant science and sourcing detail on The Science page.

Five formulations.One forest.

Forest Calm Oil

The Research

Clarity Oil

The Research

Stress Relief Oil

The Research

Mood Boost Oil

The Research

Euphoria Oil

The Research

The SYLVANA Diffuser

The Research

Sangre

The Research

Five formulations.
One forest.